Health1st AI Logo
Pharmacy Agent

One agent for the entire drug-industry surface

E-prescribing is its own standards universe — NCPDP SCRIPT, EPCS, benefit checks, prior auth, and the RxNorm↔NDC crosswalk that pharmacies and PBMs run on. The Pharmacy Agent owns all of it, connecting EHRs, pharmacies, PBMs and pharma over Surescripts, CoverMyMeds and DrFirst.

  • NCPDP SCRIPT v2023011 · EPCS · ePA
  • Real-Time Prescription Benefit (RTPB v13 ↔ CARIN RTPBC, Jan 2027)
  • RxNorm ↔ NDC normalization & medication history
See it in the fleet
EHR order · MedicationRequestNCPDP SCRIPT NewRx
Drug   : ATORVASTATIN CALCIUM 20 MG tablet
RxNorm : 617311   (clinical drug concept)
NDC    : 59651-608  (dispensing package)
Sig    : Take 1 tablet by mouth once daily
Qty    : 30        Refills: 3
Txn    : SCRIPT v2023011 · NewRx
RTPB
benefit & price
EPCS
if controlled
Route
Surescripts

The agent normalizes the drug from RxNorm (clinical concept 617311) to the exact NDC package (59651-608) for dispensing, surfaces real-time benefit, and routes the NewRx to the pharmacy over Surescripts.

In short

The Pharmacy Agent owns the drug-industry interoperability surface. It handles NCPDP SCRIPT v2023011 e-prescribing (NewRx, RxRenewal, RxChange, CancelRx, RxFill), EPCS for controlled substances, electronic prior auth, Real-Time Prescription Benefit (bridging RTPB v13 and the CARIN RTPBC FHIR IG required January 2027), Formulary & Benefit, medication history, and RxNorm↔NDC normalization — routing to Surescripts, CoverMyMeds and DrFirst. Buyers: pharmacies, PBMs, e-Rx/EHR vendors, payers and pharma.
v2023011
NCPDP SCRIPT
full transaction set
RTPB v13
↔ CARIN RTPBC
FHIR path req. Jan 2027
RxNorm↔NDC
Drug normalization
concept ↔ package
3 networks
Routing
Surescripts · CoverMyMeds · DrFirst
A real prescription

ATORVASTATIN CALCIUM, from order to pharmacy

The agent normalizes the drug from its RxNorm concept to the exact NDC package, checks benefit, applies EPCS or ePA if needed, and routes the NewRx — all on standards.

EHR order · MedicationRequestNCPDP SCRIPT NewRx
Drug   : ATORVASTATIN CALCIUM 20 MG tablet
RxNorm : 617311   (clinical drug concept)
NDC    : 59651-608  (dispensing package)
Sig    : Take 1 tablet by mouth once daily
Qty    : 30        Refills: 3
Txn    : SCRIPT v2023011 · NewRx
RTPB
benefit & price
EPCS
if controlled
Route
Surescripts

The agent normalizes the drug from RxNorm (clinical concept 617311) to the exact NDC package (59651-608) for dispensing, surfaces real-time benefit, and routes the NewRx to the pharmacy over Surescripts.

How e-prescribing runs

From click to pharmacy, on standards

A four-step flow that turns a clinician's order into a routed, benefit-checked, reconciled prescription.

  1. 1

    1 · Prescribe & normalize

    The clinician selects a drug; the agent normalizes it from the FHIR MedicationRequest and RxNorm concept to the exact NDC package for dispensing, and validates the sig, quantity and refills.

  2. 2

    2 · Check benefit (RTPB)

    Real-Time Prescription Benefit returns patient-specific coverage, cost and covered alternatives in-workflow — bridging NCPDP RTPB v13 and the CARIN RTPBC FHIR IG (required January 2027).

  3. 3

    3 · Authorize (EPCS / ePA)

    Controlled substances go through EPCS with DEA-compliant identity and two-factor signing; if the payer requires prior auth, electronic prior auth (ePA) assembles and submits the request.

  4. 4

    4 · Route & reconcile

    The NewRx is routed to the pharmacy via Surescripts / CoverMyMeds / DrFirst, and RxRenewal, RxChange, CancelRx and RxFill responses flow back for medication reconciliation.

Capabilities

Everything the Pharmacy Agent covers

The full drug-industry surface — e-prescribing, benefit, prior auth, identifiers, networks and supply chain — in one agent.

NCPDP SCRIPT v2023011 e-prescribing

Full transaction set — NewRx, RxRenewal, RxChange, CancelRx and RxFill — mapped cleanly between EHR/FHIR MedicationRequest and NCPDP SCRIPT.

EPCS for controlled substances

Electronic Prescribing of Controlled Substances with DEA-compliant identity proofing, two-factor signing, audit and fraud-signal detection.

Real-Time Prescription Benefit

In-workflow benefit, price and covered-alternative surfacing, bridging NCPDP RTPB v13 and the CARIN RTPBC FHIR IG (required January 2027).

Electronic prior auth (ePA)

NCPDP ePA plus Da Vinci PAS/DTR to auto-assemble documentation, predict approval and keep the script moving without phone-and-fax delays.

Medication history & Formulary/Benefit

SCRIPT RxHistoryRequest for reconciliation across sources, plus NCPDP Formulary & Benefit for coverage and alternative-drug suggestions.

RxNorm ↔ NDC normalization

Move between clinical drug concepts (RxNorm) and dispensing-level identifiers (NDC), the crosswalk pharmacies, PBMs and claims all depend on.

Network routing

Managed connectivity to Surescripts, CoverMyMeds and DrFirst, so a prescription reaches the right pharmacy over the right network.

Drug supply chain (DSCSA)

GS1 serialization and EPCIS support for Drug Supply Chain Security Act traceability and product verification.

Who buys the pharmacy module

The Pharmacy Agent opens the drug-industry buyer set on top of the clinical core:

  • Pharmacies & PBMs — e-Rx, RTPB, med history, claims
  • e-Prescribing & EHR vendors — embed SCRIPT/FHIR
  • Payers — RTPB and electronic prior auth (ePA)
  • Pharma manufacturers — DSCSA, patient-support / hub

Security & Compliance

Enterprise-grade trust, stated honestly

Protecting PHI is non-negotiable. Here's exactly where our certifications stand — no overclaiming.

HIPAAActive

Compliant · BAAs available

SOC 2 Type IIIn Progress

Audit in progress

HITRUST CSFOn Roadmap

On roadmap

HL7 · FHIRCore

Native, by design

AWS HIPAA-eligible infrastructure · Business Associate Agreements (BAAs) · Encryption in transit & at rest · See our security details →

Frequently asked questions

Modernizing e-prescribing or pharmacy benefit?

See the Pharmacy Agent run NCPDP SCRIPT, RTPB and RxNorm↔NDC normalization on your own drug and benefit data.

Talk to our team